Foah and Kefraya, most of whose residents are Shia Muslims, have been encircled by rebels and al-Qaeda-linked Sunni jihadists since March 2015.
Madaya and Zabadani, which are predominantly Sunni, have meanwhile been besieged since June 2015 by the Syrian army and fighters from Lebanon's Shia Islamist Hezbollah movement.
The evacuation deal has been brokered by Iran and Qatar. But critics say it amounts to forced demographic change.
Some 4.7 million people live in hard-to-reach and besieged areas in Syria, including 644,000 in UN-declared besieged locations.
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