The centrist candidate Emmanuel Macron said Ms Le Pen's nationalist proposals amounted to "economic warfare".
But she was also accused from the right of not being tough enough on France's membership of the EU.
Francois Fillon, meanwhile, said that France needed Europe when up against the US and China.
Ms Le Pen, leader of the National Front (FN) party, promised to restore control of France's borders and scrap the euro, or else hold a referendum on EU membership.
Speaking alongside 10 other candidates as things got a little heated in the second of three televised French presidential election debates, she said that her presidency would improve the lives of French citizens.
France holds its first round of voting on 23 April. Unless one candidate wins more than 50% of the vote, the two leading contenders will go to a second round on 7 May.
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